BPDE-DNA Antikörper

Produktnummer ABIN1105553

Der Maus Monoklonal Anti-BPDE-DNA Antikörper wurde für EIA, IF, IHC (p) und IP validiert. Er ist geeignet, BPDE-DNA in Proben von Säugetier zu detektieren.

Kurzübersicht für BPDE-DNA Antikörper (ABIN1105553)

Target: BPDE-DNA (Benzo[a]pyrenediol Epoxide Modified DNA (BPDE-DNA))

Reaktivität: Säugetier

Wirt: Maus

Klonalität: Monoklonal

Applikation: Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Klon: 5D11

Produktdetails anti-BPDE-DNA Antikörper

Aufreinigung: Protein G

Immunogen: BPDE-I-DNA complexed with methylated BSA

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu BPDE-DNA

Target: BPDE-DNA (Benzo[a]pyrenediol Epoxide Modified DNA (BPDE-DNA))

Andere Bezeichnung: BPDE-DNA

Hintergrund: A number of chemicals, including polycyclic aromatic hydrocarbons (PAHs), have been shown to bind to DNA. This DNA damage can occur both early and late in the malignant process, thereby acting as an initiator and assisting in the progression of tumors. PAHs are released into the environment following incomplete combustion of organic materials. The most common sources of PAHs are from smoking and from consuming broiled or grilled foods. Human exposure to PAHs comes from various occupational, environmental, dietary and medicinal sources. Benzo[a]pyrene is a representative PAH. Antibodies to benzo[a]pyrenediol-epoxide modified DNA (BPDE-DNA) can be used to identify polycyclic aromatic hydrocarbon (PAH)-DNA adducts. Exposure to this group of compounds is believed to be carcinogenic.